Endocrine Abstracts

Context: Vitamin D is a fat-soluble vitamin which requires the hydroxylation into 1,25-dihydroxyvitamin D (1,25-(OH)2D3) to be fully active. Vitamin D deficiency is a worldwide health problem associated to a wide range of acute and chronic diseases. On other hand, vitamin D supplementation has been proposed to reduced the risk of metabolic dysfunctions including obesity, type 2 diabetes and cardiovascular disease. Vitamin D interacts with the epigenetic m...

Introduction: There are few studies either hospital bases or population based in Africa and in Angola we also have the same situation regarding endocrinology data. With this paper, the Angolan Society of Endocrinology Diabetes and Metabolism (SAEDM), wants to contribute to the systematic and continued study of endocrine pathology in Angola.Objective: Study of the casuistic of endocrine pathology in ambulatory setting regarding the year 2015.<p class=...

Introduction: Diabetes Mellitus is a chronic disease that has serious effects on the morbi-mortality. Diabetes type 1 is less prevalent, representing 5–10% of the total cases. Data collected in Africa are scarce, and prevalence and incidence at sub - Saharan Africa are about 3-12/100,000 and 1.1–2.1/100,000 people, respectively. The Angolan reality is not known.Objective: To show the casuistic of diabetes type 1 obtained from the ambulatory con...

Introduction: POEMS syndrome is a rare multisystemic disorder including polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes. We aim to describe the course of the endocrine disease in the context of this paraneoplastic syndrome.Methods: 69 patients with POEMS have been under the MDT care in our hospital. Data is currently available for 32 patients who attended the joint haematological/neurological/endocr...

Introduction: Adrenal masses (AM) are being increasingly diagnosed but only a small portion will need surgical treatment.Methods: We retrospectively reviewed patients referred to the Endocrinology Clinic that underwent adrenalectomy between 1996 and 2023.Results: We included 57 patients. Most AM were diagnosed incidentally (53%) and had a median size of 32 (25) mm. Forty (70%) patients had hormonal hypersecretion (HH): pheocromocyt...

Introduction: Deficiency of 11-beta hydroxylase (11-HD) accounts for 5% of the causes of congenital adrenal hyperplasia (CAH), with an incidence of 1:100,000. The classic form phenotype consists in an excess of androgens and mineralocorticoids, which clinically translates into hypertension and hypokalaemia. In boys, there may be an increase in penis size, early adrenarche, increased growth velocity, and advancing bone age.Clinical case: We present a case...

Reproduction is tightly coupled to body energy and metabolic status. GnRH neurons, the final output pathway for the brain control of reproduction, directly or indirectly receive and integrate multiple signals, including metabolic cues regulating reproductive function. Yet, the molecular underpinnings of such phenomenon remain largely unfolded. AMP-activated protein kinase (AMPK), a fundamental cellular sensor that becomes activated in conditions of energy deficit, has a key ro...

Prevalence of metabolic syndrome (MetS) and type-2 Diabetes (T2D) is growing dramatically worldwide. Loss of phenotypic flexibility, i.e. the difficulty to cope with different stressors to maintain metabolic homeostasis, contributes critically to the development of MetS/T2DM. Thus, it is essential to identify the key modifiers of phenotypic plasticity that define an individual’s susceptibility to develop T2DM. In this scenario, emerging evidence indicates that, under adve...

Introduction:: Gender dysphoria (GD) is featured by significant difference between the individual’s expressed gender and the gender others would assign him or her, with marked distress in social and occupational functionality, according to DSM-V classification. We report the experience in the clinical evaluation and the results of hormonal therapy and sex reassignment surgery in a hospital center.Methods:: It was conducted a retrospective analysis o...

Dietary fat influences systemic inflammatory status, which, in turn, determines the progression of age-associated diseases. Peripheral blood mononuclear cells (PBMCs) comprise a subset of white blood cells placed at the crossroad between diet and inflammation, in that they play a key role in the immune/inflammatory system and their gene expression pattern is influenced by diet. Since the somatostatin (SST), cortistatin (CORT) and ghrelin systems have been shown to modulate the...